Effect of Novel Pyrrolo[3,4-<i>d</i>]pyridazinone Derivatives on Lipopolysaccharide-Induced Neuroinflammation

Effect of Novel Pyrrolo[3,4-<i>d</i>]pyridazinone Derivatives on Lipopolysaccharide-Induced Neuroinflammation

Neuroinflammation is considered to be one of the potential causes for the development of neurodegenerative diseases, including Alzheimer’s disease. In this study, we evaluated the effect of four newly synthesized pyrrolo[3,4-<i>d</i>]pyridazinone derivatives on the neuron-like PC12 cells...

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Bibliographic Details
Main Authors: Karolina Wakulik, Benita Wiatrak, Łukasz Szczukowski, Dorota Bodetko, Marta Szandruk-Bender, Agnieszka Dobosz, Piotr Świątek, Kazimierz Gąsiorowski
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
neuroinflammation
Alzheimer’s disease
lipopolysaccharide
LPS
pyridazinone
NSAID
Online Access:https://www.mdpi.com/1422-0067/21/7/2575

Internet

https://www.mdpi.com/1422-0067/21/7/2575

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