Ideal vs. real: a systematic review on handling covariates in randomized controlled trials

Abstract Background In theory, efficient design of randomized controlled trials (RCTs) involves randomization algorithms that control baseline variable imbalance efficiently, and corresponding analysis involves pre-specified adjustment for baseline covariates. This review sought to explore technique...

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Bibliographic Details
Main Authors: Jody D. Ciolino, Hannah L. Palac, Amy Yang, Mireya Vaca, Hayley M. Belli
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Medical Research Methodology
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12874-019-0787-8