Alteration of Dynein Function Affects α-Synuclein Degradation via the Autophagosome-Lysosome Pathway

Alteration of Dynein Function Affects α-Synuclein Degradation via the Autophagosome-Lysosome Pathway

Growing evidence suggests that dynein dysfunction may be implicated in the pathogenesis of neurodegeneration. It plays a central role in aggresome formation, the delivery of autophagosome to lysosome for fusion and degradation, which is a pro-survival mechanism essential for the bulk degradation of...

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Bibliographic Details
Main Authors: Da Li, Ji-Jun Shi, Cheng-Jie Mao, Sha Liu, Jian-Da Wang, Jing Chen, Fen Wang, Ya-Ping Yang, Wei-Dong Hu, Li-Fang Hu, Chun-Feng Liu
Format: Article
Language:English
Published: MDPI AG 2013-12-01
Series:International Journal of Molecular Sciences
Subjects:
dynein
α-synuclein
Parkinson’s disease
autophagy
autolysosome
Online Access:http://www.mdpi.com/1422-0067/14/12/24242

Internet

http://www.mdpi.com/1422-0067/14/12/24242

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