The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA

The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA

The ADAR RNA-editing enzymes deaminate adenosine bases to inosines in cellular RNAs. Aberrant interferon expression occurs in patients in whom ADAR1 mutations cause Aicardi-Goutières syndrome (AGS) or dystonia arising from striatal neurodegeneration. Adar1 mutant mouse embryos show aberrant interfer...

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Bibliographic Details
Main Authors: Niamh M. Mannion, Sam M. Greenwood, Robert Young, Sarah Cox, James Brindle, David Read, Christoffer Nellåker, Cornelia Vesely, Chris P. Ponting, Paul J. McLaughlin, Michael F. Jantsch, Julia Dorin, Ian R. Adams, A.D.J. Scadden, Marie Öhman, Liam P. Keegan, Mary A. O’Connell
Format: Article
Language:English
Published: Elsevier 2014-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714009103

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http://www.sciencedirect.com/science/article/pii/S2211124714009103

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