Pluripotent stem cell-derived models of neurological diseases reveal early transcriptional heterogeneity

Pluripotent stem cell-derived models of neurological diseases reveal early transcriptional heterogeneity

Abstract Background Many neurodegenerative diseases develop only later in life, when cells in the nervous system lose their structure or function. In many forms of neurodegenerative diseases, this late-onset phenomenon remains largely unexplained. Results Analyzing single-cell RNA sequencing from Al...

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Bibliographic Details
Main Authors: Matan Sorek, Walaa Oweis, Malka Nissim-Rafinia, Moria Maman, Shahar Simon, Cynthia C. Hession, Xian Adiconis, Sean K. Simmons, Neville E. Sanjana, Xi Shi, Congyi Lu, Jen Q. Pan, Xiaohong Xu, Mahmoud A. Pouladi, Lisa M. Ellerby, Feng Zhang, Joshua Z. Levin, Eran Meshorer
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Genome Biology
Subjects:
Transcriptional heterogeneity
Single cell
scRNA-seq
Neurological diseases
Neurodegenerative diseases
Huntington’s disease
Online Access:https://doi.org/10.1186/s13059-021-02301-6

Internet

https://doi.org/10.1186/s13059-021-02301-6

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