Hyperactivation of D1 and A2A receptors contributes to cognitive dysfunction in Huntington's disease

Hyperactivation of D1 and A2A receptors contributes to cognitive dysfunction in Huntington's disease

Stimulation of dopamine D1 receptor (D1R) and adenosine A2A receptor (A2AR) increases cAMP-dependent protein kinase (PKA) activity in the brain. In Huntington's disease, by essentially unknown mechanisms, PKA activity is increased in the hippocampus of mouse models and patients and contributes...

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Bibliographic Details
Main Authors: Shiraz Tyebji, Ana Saavedra, Paula M. Canas, Anna Pliassova, José M. Delgado-García, Jordi Alberch, Rodrigo A. Cunha, Agnès Gruart, Esther Pérez-Navarro
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:Neurobiology of Disease
Subjects:
Adenosine
cAMP
Dopamine
Hippocampus
PKA pathway
R6/1 mice
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114003428

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http://www.sciencedirect.com/science/article/pii/S0969996114003428

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