A decreased expression of angiopoietin-like 3 is protective against atherosclerosis in apoE-deficient mice

A decreased expression of angiopoietin-like 3 is protective against atherosclerosis in apoE-deficient mice

KK/Snk mice (previously KK/San) possessing a recessive mutation (hypl) of the angiopoietin-like 3 (Angptl3) gene homozygously exhibit a marked reduction of VLDL due to the decreased Angptl3 expression. Recently, we proposed that Angptl3 is a new class of lipid metabolism modulator regulating VLDL tr...

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Bibliographic Details
Main Authors: Yosuke Ando, Tetsuya Shimizugawa, Shigehito Takeshita, Mitsuru Ono, Mitsuru Shimamura, Ryuta Koishi, Hidehiko Furukawa
Format: Article
Language:English
Published: Elsevier 2003-06-01
Series:Journal of Lipid Research
Subjects:
hypolipidemia
hyperlipidemia
triglyceride-rich lipoproteins
very low density lipoprotein
apolipoprotein B
lipoprotein lipase
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520311238

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http://www.sciencedirect.com/science/article/pii/S0022227520311238

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