Synergistically Enhanced Inhibitory Effects of Pullulan Nanoparticle-Mediated Co-Delivery of Lovastatin and Doxorubicin to Triple-Negative Breast Cancer Cells

Synergistically Enhanced Inhibitory Effects of Pullulan Nanoparticle-Mediated Co-Delivery of Lovastatin and Doxorubicin to Triple-Negative Breast Cancer Cells

Abstract Triple-negative breast cancer (TNBC) is a subtype of breast cancer that is prone to drug resistance and difficult to treat. In this study, we grafted water-soluble pullulan with lovastatin (LV) to develop a novel amphiphilic conjugate, pullulan-encapsulated LV (PLV). The PLV conjugate was s...

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Bibliographic Details
Main Authors: Di Wu, Yao Chen, Shun Wen, Yi Wen, Rong Wang, Qiuting Zhang, Ge Qin, Huimei Yi, Mi Wu, Lu Lu, Xiaojun Tao, Xiyun Deng
Format: Article
Language:English
Published: SpringerOpen 2019-09-01
Series:Nanoscale Research Letters
Subjects:
Lovastatin
Triple-negative breast cancer
Amphiphilic conjugate
Synergistic effect
Nuclear magnetic resonance spectroscopy
Online Access:http://link.springer.com/article/10.1186/s11671-019-3146-0

Internet

http://link.springer.com/article/10.1186/s11671-019-3146-0

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