NAAG peptidase inhibition in the periaqueductal gray and rostral ventromedial medulla reduces flinching in the formalin model of inflammation

NAAG peptidase inhibition in the periaqueductal gray and rostral ventromedial medulla reduces flinching in the formalin model of inflammation

<p>Abstract</p> <p>Background</p> <p>Metabotropic glutamate receptors (mGluRs) have been identified as significant analgesic targets. Systemic treatments with inhibitors of the enzymes that inactivate the peptide transmitter N-acetylaspartylglutamate (NAAG), an mGluR3 a...

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Bibliographic Details
Main Authors: Yamada Toshihiko, Zuo Daiying, Yamamoto Tatsuo, Olszewski Rafal T, Bzdega Tomasz, Moffett John R, Neale Joseph H
Format: Article
Language:English
Published: SAGE Publishing 2012-09-01
Series:Molecular Pain
Subjects:
Analgesia
NAAG
PAG
RVM
mGluR3
LY341495
Inflammatory pain
Microdialysis
Online Access:http://www.molecularpain.com/content/8/1/67

Internet

http://www.molecularpain.com/content/8/1/67

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