The Motion of An Inv Nodal Cilium: a Realistic Model Revealing Dynein-Driven Ciliary Motion with Microtubule Mislocalization

The Motion of An Inv Nodal Cilium: a Realistic Model Revealing Dynein-Driven Ciliary Motion with Microtubule Mislocalization

Background/Aims: Nodal cilia that rotate in the ventral node play an important role in establishing left-right asymmetry during embryogenesis; however, inv mutant cilia present abnormal movement and induce laterality defects. The mechanism of their motility, which is regulated by dynein activation a...

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Bibliographic Details
Main Authors: Yanan Yu, Kyosuke Shinohara, Huanming Xu, Zhenfeng Li, Tomoki Nishida, Hiroshi Hamada, Yuanqing Xu, Jingqi Zhou, Daisy Shao, Xiangchen Li, Duanduan Chen
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-12-01
Series:Cellular Physiology and Biochemistry
Subjects:
Inv mutant nodal cilia
Dynein activation
Computational simulation
Ultra-high voltage electron tomography
Online Access:https://www.karger.com/Article/FullText/496038

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https://www.karger.com/Article/FullText/496038

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