Protective Effect of Metformin Against Walker 256 Tumor Growth is Not Dependent on Metabolism Improvement

Protective Effect of Metformin Against Walker 256 Tumor Growth is Not Dependent on Metabolism Improvement

Background/Aims: The objective of the current work was to test the effect of metformin on the tumor growth in rats with metabolic syndrome. Methods: We obtained pre-diabetic hyperinsulinemic rats by neonatal treatment with monosodium L-glutamate (MSG), which were chronically treated every day, from...

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Main Authors: Claudinéia Conationi da Silva Franco, Rosiane Aparecida Miranda, Júlio Cezar de Oliveira, Luiz Felipe Barella, Aryane Rodrigues Agostinho, Kelly Valério Prates, Ananda Malta, Amanda Bianchi Trombini, Rosana Torrezan, Clarice Gravena, Laize P. Tófolo, Juliane Rocha de Sant'Anna, Marialba Avezum Alves de Castro Prado, Camila Oliveira de Souza, Helenir Medri de Souza, Evandro José Beraldi, Paulo Cezar de Freitas Mathias
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Metformin
Walker 256 tumor
Apoptosis
Metabolism
Online Access:http://www.karger.com/Article/FullText/366390

Internet

http://www.karger.com/Article/FullText/366390

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