Pharmacokinetics and Immunological Effects of Romidepsin in Rhesus Macaques

Pharmacokinetics and Immunological Effects of Romidepsin in Rhesus Macaques

HIV/SIV persistence in latent reservoirs requires lifelong antiretroviral treatment and calls for effective cure strategies. Romidepsin (RMD), a histone deacetylase inhibitor, was reported to reactivate HIV/SIV from reservoirs in virus-suppressed individuals. We characterized in detail the pharmacok...

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Bibliographic Details
Main Authors: Adam J. Kleinman, Cuiling Xu, Mackenzie L. Cottrell, Ranjit Sivanandham, Egidio Brocca-Cofano, Tammy Dunsmore, Angela Kashuba, Ivona Pandrea, Cristian Apetrei
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
romidepsin
histone deacetylase inhibitors
latency reversing agents
human immunodeficiency virus
simian immunodeficiency virus
HIV latency
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.579158/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.579158/full

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