MicroRNA-23a-3p Down-Regulation in Active Pulmonary Tuberculosis Patients with High Bacterial Burden Inhibits Mononuclear Cell Function and Phagocytosis through TLR4/TNF-α/TGF-β1/IL-10 Signaling via Targeting IRF1/SP1

MicroRNA-23a-3p Down-Regulation in Active Pulmonary Tuberculosis Patients with High Bacterial Burden Inhibits Mononuclear Cell Function and Phagocytosis through TLR4/TNF-α/TGF-β1/IL-10 Signaling via Targeting IRF1/SP1

The aim of this study is to explore the role of microRNAs (miR)-21/23a/146a/150/155 targeting the toll-like receptor pathway in active tuberculosis (TB) disease and latent TB infection (LTBI). Gene expression levels of the five miRs and predicted target genes were assessed in peripheral blood mononu...

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Bibliographic Details
Main Authors: Yung-Che Chen, Chiu Ping Lee, Chang-Chun Hsiao, Po-Yuan Hsu, Ting-Ya Wang, Chao-Chien Wu, Tung-Ying Chao, Sum-Yee Leung, Yu-Ping Chang, Meng-Chih Lin
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
active pulmonary TB disease
latent TB infection
miR-23a-3p
IL10
TLR4
Online Access:https://www.mdpi.com/1422-0067/21/22/8587

Internet

https://www.mdpi.com/1422-0067/21/22/8587

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