Discrimination between G/C Binding Sites by Olivomycin A Is Determined by Kinetics of the Drug-DNA Interaction

Discrimination between G/C Binding Sites by Olivomycin A Is Determined by Kinetics of the Drug-DNA Interaction

Olivomycin A (OA) exerts its cytotoxic potency due to binding to the minor groove of the G/C-rich DNA and interfering with replication and transcription. Screening of the complete set of tetranucleotide G/C sites by electrophoretic mobility gel shift assay (EMSA) revealed that the sites containing c...

Full description

Bibliographic Details
Main Authors: Artemy D. Beniaminov, Galina V. Chashchina, Mikhail A. Livshits, Olga I. Kechko, Vladimir A. Mitkevich, Olga K. Mamaeva, Anna N. Tevyashova, Alexander A. Shtil, Anna K. Shchyolkina, Dmitry N. Kaluzhny
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
Olivomycin A
DNA binding
kinetics
sequence specificity
Online Access:https://www.mdpi.com/1422-0067/21/15/5299

Internet

https://www.mdpi.com/1422-0067/21/15/5299

Similar Items