A PB1-K577E Mutation in H9N2 Influenza Virus Increases Polymerase Activity and Pathogenicity in Mice

H9N2 avian influenza viruses are present in poultry worldwide. These viruses are considered to have pandemic potential, because recent isolates can recognize human-type receptor and several sporadic human infections have been reported. In this study, we aimed to identify mutations related to mammali...

Full description

Bibliographic Details
Main Authors: Haruhiko Kamiki, Hiromichi Matsugo, Tomoya Kobayashi, Hiroho Ishida, Akiko Takenaka-Uema, Shin Murakami, Taisuke Horimoto
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Viruses
Subjects:
PB1
Online Access:https://www.mdpi.com/1999-4915/10/11/653