Effects of β1-adrenergic receptor blockade on the cerebral microcirculation in the normal state and during global brain ischemia/reperfusion injury in rabbits

Effects of β1-adrenergic receptor blockade on the cerebral microcirculation in the normal state and during global brain ischemia/reperfusion injury in rabbits

Abstract Background Although recent studies using experimental models of ischemic brain injury indicate that systemically-administered β1-blockers have potential protective effects on the cerebrovascular system, the precise mechanisms remain unclear. In addition to their cardiovascular effects, wate...

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Bibliographic Details
Main Authors: Nobumasa Asano, Sohei Hishiyama, Tadahiko Ishiyama, Masakazu Kotoda, Takashi Matsukawa
Format: Article
Language:English
Published: BMC 2020-02-01
Series:BMC Pharmacology and Toxicology
Subjects:
β1-adrenergic receptor blockade
Ischemia/reperfusion injury
Cerebral microvasculature
Vasodilation
Online Access:http://link.springer.com/article/10.1186/s40360-020-0394-7

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http://link.springer.com/article/10.1186/s40360-020-0394-7

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