Tibolone modulates neuronal plasticity through regulating Tau, GSK3β/Akt/PI3K pathway and CDK5 p35/p25 complexes in the hippocampus of aged male mice

Tibolone modulates neuronal plasticity through regulating Tau, GSK3β/Akt/PI3K pathway and CDK5 p35/p25 complexes in the hippocampus of aged male mice

Aging is a key risk factor for cognitive decline and age-related neurodegenerative disorders. Also, an age-related decrease in sex steroid hormones may have a negative impact on the formation of neurofibrillary tangles (NFTs); these hormones can regulate Tau phosphorylation and the principal kinase...

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Bibliographic Details
Main Authors: Teresa Neri-Gómez, Judith Espinosa-Raya, Sofía Díaz-Cintra, Julia Segura-Uribe, Sandra Orozco-Suárez, Juan Manuel Gallardo, Christian Guerra-Araiza
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2017-01-01
Series:Neural Regeneration Research
Subjects:
nerve regeneration; Tibolone; hippocampus; aged mice; sex steroids; Akt; GSK3β; PI3K; neural plasticity; Tau; neurofibrillary tangles; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=4;spage=588;epage=595;aulast=Neri-Gómez

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=4;spage=588;epage=595;aulast=Neri-Gómez

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