The Role of the L-Type Ca2+ Channel in Altered Metabolic Activity in a Murine Model of Hypertrophic Cardiomyopathy

The Role of the L-Type Ca2+ Channel in Altered Metabolic Activity in a Murine Model of Hypertrophic Cardiomyopathy

Heterozygous mice (αMHC403/+) expressing the human disease-causing mutation Arg403Gln exhibit cardinal features of hypertrophic cardiomyopathy (HCM) including hypertrophy, myocyte disarray, and increased myocardial fibrosis. Treatment of αMHC403/+mice with the L-type calcium channel (ICa-L) antagoni...

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Bibliographic Details
Main Authors: Helena M. Viola, PhD, Victoria P.A. Johnstone, PhD, Henrietta Cserne Szappanos, PhD, Tara R. Richman, PhD, Tatiana Tsoutsman, PhD, Aleksandra Filipovska, PhD, Christopher Semsarian, MD, PhD, Jonathan G. Seidman, PhD, Christine E. Seidman, MD, PhD, Livia C. Hool, PhD
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:JACC: Basic to Translational Science
Subjects:
calcium
cardiomyopathy
L-type calcium channel
mitochondria
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X16000115

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http://www.sciencedirect.com/science/article/pii/S2452302X16000115

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