A BAC transgenic mouse model reveals neuron subtype-specific effects of a Generalized Epilepsy with Febrile Seizures Plus (GEFS+) mutation

A BAC transgenic mouse model reveals neuron subtype-specific effects of a Generalized Epilepsy with Febrile Seizures Plus (GEFS+) mutation

Mutations in the voltage-gated sodium channel SCN1A are responsible for a number of seizure disorders including Generalized Epilepsy with Febrile Seizures Plus (GEFS+) and Severe Myoclonic Epilepsy of Infancy (SMEI). To determine the effects of SCN1A mutations on channel function in vivo, we generat...

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Bibliographic Details
Main Authors: Bin Tang, Karoni Dutt, Ligia Papale, Raffaella Rusconi, Anupama Shankar, Jessica Hunter, Sergio Tufik, Frank H. Yu, William A. Catterall, Massimo Mantegazza, Alan L. Goldin, Andrew Escayg
Format: Article
Language:English
Published: Elsevier 2009-07-01
Series:Neurobiology of Disease
Subjects:
Sodium channel
SCN1A
GEFS+
SMEI
Epilepsy
Mutation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109000849

Internet

http://www.sciencedirect.com/science/article/pii/S0969996109000849

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