Local neutral networks help maintain inaccurately replicating ribozymes.

The error threshold of replication limits the selectively maintainable genome size against recurrent deleterious mutations for most fitness landscapes. In the context of RNA replication a distinction between the genotypic and the phenotypic error threshold has been made; where the latter concerns th...

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Bibliographic Details
Main Authors: András Szilágyi, Ádám Kun, Eörs Szathmáry
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4192543?pdf=render