miR-429-CRKL axis regulates clear cell renal cell carcinoma malignant progression through SOS1/MEK/ERK/MMP2/MMP9 pathway

miR-429-CRKL axis regulates clear cell renal cell carcinoma malignant progression through SOS1/MEK/ERK/MMP2/MMP9 pathway

The pathogenesis and tumorigenesis of clear cell renal cell carcinoma (ccRCC) remain unclear. The deregulations of miR-429, a member of miR-200 family, and v-crk sarcoma virus CT10 oncogene homologue (avian)-like (CRKL), an adaptor protein of CRK family, are involved in the development, metastasis a...

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Bibliographic Details
Main Authors: Jinxia Wang, Chengyi Wang, Qian Li, Chunmei Guo, Weibin Sun, Dongting Zhao, Sixiong Jiang, Lihong Hao, Yuxiang Tian, Shuqing Liu, Ming-Zhong Sun
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Clear cell renal carcinoma(ccRCC)
MiR-429-CRKL axis
Tumorigenesis
SOS1/MEK/ERK/MMP2/MMP9 pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220304078

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http://www.sciencedirect.com/science/article/pii/S0753332220304078

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