Glioma cells require one-carbon metabolism to survive glutamine starvation

Glioma cells require one-carbon metabolism to survive glutamine starvation

Abstract Cancer cells optimize nutrient utilization to supply energetic and biosynthetic pathways. This metabolic process also includes redox maintenance and epigenetic regulation through nucleic acid and protein methylation, which enhance tumorigenicity and clinical resistance. However, less is kno...

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Bibliographic Details
Main Authors: Kazuhiro Tanaka, Takashi Sasayama, Hiroaki Nagashima, Yasuhiro Irino, Masatomo Takahashi, Yoshihiro Izumi, Takiko Uno, Naoko Satoh, Akane Kitta, Katsusuke Kyotani, Yuichi Fujita, Mitsuru Hashiguchi, Tomoaki Nakai, Masaaki Kohta, Yoichi Uozumi, Masakazu Shinohara, Kohkichi Hosoda, Takeshi Bamba, Eiji Kohmura
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Acta Neuropathologica Communications
Subjects:
One-carbon metabolism
Serine synthesis
Glutamine starvation
Glioblastoma multiforme
Online Access:https://doi.org/10.1186/s40478-020-01114-1

Internet

https://doi.org/10.1186/s40478-020-01114-1

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