Genome-wide analysis suggests the importance of vascular processes and neuroinflammation in late-life antidepressant response

Genome-wide analysis suggests the importance of vascular processes and neuroinflammation in late-life antidepressant response

Abstract Antidepressant outcomes in older adults with depression is poor, possibly because of comorbidities such as cerebrovascular disease. Therefore, we leveraged multiple genome-wide approaches to understand the genetic architecture of antidepressant response. Our sample included 307 older adults...

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Bibliographic Details
Main Authors: Victoria S. Marshe, Malgorzata Maciukiewicz, Anne-Christin Hauschild, Farhana Islam, Li Qin, Arun K. Tiwari, Etienne Sibille, Daniel M. Blumberger, Jordan F. Karp, Alastair J. Flint, Gustavo Turecki, Raymond W. Lam, Roumen V. Milev, Benicio N. Frey, Susan Rotzinger, Jane A. Foster, Sidney H. Kennedy, James L. Kennedy, Benoit H. Mulsant, Charles F. Reynolds, Eric J. Lenze, Daniel J. Müller
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-021-01248-3

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https://doi.org/10.1038/s41398-021-01248-3

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