Genome-wide analysis suggests the importance of vascular processes and neuroinflammation in late-life antidepressant response
Abstract Antidepressant outcomes in older adults with depression is poor, possibly because of comorbidities such as cerebrovascular disease. Therefore, we leveraged multiple genome-wide approaches to understand the genetic architecture of antidepressant response. Our sample included 307 older adults...
Main Authors: | Victoria S. Marshe, Malgorzata Maciukiewicz, Anne-Christin Hauschild, Farhana Islam, Li Qin, Arun K. Tiwari, Etienne Sibille, Daniel M. Blumberger, Jordan F. Karp, Alastair J. Flint, Gustavo Turecki, Raymond W. Lam, Roumen V. Milev, Benicio N. Frey, Susan Rotzinger, Jane A. Foster, Sidney H. Kennedy, James L. Kennedy, Benoit H. Mulsant, Charles F. Reynolds, Eric J. Lenze, Daniel J. Müller |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-02-01
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Series: | Translational Psychiatry |
Online Access: | https://doi.org/10.1038/s41398-021-01248-3 |
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