Adaptive designs in clinical trials: why use them, and how to run and report them

Adaptive designs in clinical trials: why use them, and how to run and report them

Abstract Adaptive designs can make clinical trials more flexible by utilising results accumulating in the trial to modify the trial’s course in accordance with pre-specified rules. Trials with an adaptive design are often more efficient, informative and ethical than trials with a traditional fixed d...

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Bibliographic Details
Main Authors: Philip Pallmann, Alun W. Bedding, Babak Choodari-Oskooei, Munyaradzi Dimairo, Laura Flight, Lisa V. Hampson, Jane Holmes, Adrian P. Mander, Lang’o Odondi, Matthew R. Sydes, Sofía S. Villar, James M. S. Wason, Christopher J. Weir, Graham M. Wheeler, Christina Yap, Thomas Jaki
Format: Article
Language:English
Published: BMC 2018-02-01
Series:BMC Medicine
Subjects:
Statistical methods
Adaptive design
Flexible design
Interim analysis
Design modification
Seamless design
Online Access:http://link.springer.com/article/10.1186/s12916-018-1017-7

Internet

http://link.springer.com/article/10.1186/s12916-018-1017-7

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