D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction

D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction

Summary: The severe acute respiratory coronavirus 2 (SARS-CoV-2) spike (S) protein is the target of vaccine design efforts to end the coronavirus disease 2019 (COVID-19) pandemic. Despite a low mutation rate, isolates with the D614G substitution in the S protein appeared early during the pandemic an...

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Bibliographic Details
Main Authors: Sophie M.-C. Gobeil, Katarzyna Janowska, Shana McDowell, Katayoun Mansouri, Robert Parks, Kartik Manne, Victoria Stalls, Megan F. Kopp, Rory Henderson, Robert J. Edwards, Barton F. Haynes, Priyamvada Acharya
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Cell Reports
Subjects:
COVID-19
SARS-CoV-2
spike
2P
D614G
allostery
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720316193

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http://www.sciencedirect.com/science/article/pii/S2211124720316193

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