ABCA1- and ABCG1-mediated cholesterol efflux capacity of cerebrospinal fluid is impaired in Alzheimer's disease

ABCA1- and ABCG1-mediated cholesterol efflux capacity of cerebrospinal fluid is impaired in Alzheimer's disease

HDL-like particles in human cerebrospinal fluid (CSF) promote the efflux of cholesterol from astrocytes toward the neurons that rely on this supply for their functions. We evaluated whether cell cholesterol efflux capacity of CSF (CSF-CEC) is impaired in Alzheimer's disease (AD) by analyzing AD...

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Bibliographic Details
Main Authors: Cinzia Marchi, Maria Pia Adorni, Paolo Caffarra, Nicoletta Ronda, Marco Spallazzi, Federica Barocco, Daniela Galimberti, Franco Bernini, Francesca Zimetti
Format: Article
Language:English
Published: Elsevier 2019-08-01
Series:Journal of Lipid Research
Subjects:
ATP-binding cassette A1
ATP-binding cassette G1
apolipoproteins
apolipoprotein A-I
apolipoprotein E
apolipoprotein E4
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520322392

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http://www.sciencedirect.com/science/article/pii/S0022227520322392

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