Implication of Tumor Microenvironment in Chemoresistance: Tumor-Associated Stromal Cells Protect Tumor Cells from Cell Death

Implication of Tumor Microenvironment in Chemoresistance: Tumor-Associated Stromal Cells Protect Tumor Cells from Cell Death

Tumor development principally occurs following the accumulation of genetic and epigenetic alterations in tumor cells. These changes pave the way for the transformation of chemosensitive cells to chemoresistant ones by influencing the uptake, metabolism, or export of drugs at the cellular level. Nume...

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Bibliographic Details
Main Authors: Jean-Pierre Delord, Magali Castells, Bettina Couderc, Benoît Thibault
Format: Article
Language:English
Published: MDPI AG 2012-07-01
Series:International Journal of Molecular Sciences
Subjects:
microenvironment
cancer
chemoresistance
apoptosis
Online Access:http://www.mdpi.com/1422-0067/13/8/9545

Internet

http://www.mdpi.com/1422-0067/13/8/9545

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