Somatostatin receptor 1,2 and 5 activation leads to C6 glioma growth arrest in vitro and in vivo; analysis of the intracellular pathways involved

Somatostatin receptor 1,2 and 5 activation leads to C6 glioma growth arrest in vitro and in vivo; analysis of the intracellular pathways involved

We report that somatostain receptor (SSTR) 1,2 and 5 activation by selective agonista, cause C6 cell growth arrest through PTPn-dependent dephosphorylation of ERK1/2 in vitro and after xenografting in nude mice. Individual SSTR agonist desplayed different efficacy and potecy showing partial synergis...

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Bibliographic Details
Main Authors: M. Gatti, A. Pattarozzi, R. Würth, F. Angeletti, F. Barbieri, T. Florio
Format: Article
Language:English
Published: PAGEPress Publications 2011-01-01
Series:Journal of Biological Research
Subjects:
somatostatin, somatostatine receptor, gliomas
Online Access:http://www.pagepressjournals.org/index.php/jbr/article/view/4649

Internet

http://www.pagepressjournals.org/index.php/jbr/article/view/4649

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