γ-Protocadherins Interact with Neuroligin-1 and Negatively Regulate Dendritic Spine Morphogenesis

γ-Protocadherins Interact with Neuroligin-1 and Negatively Regulate Dendritic Spine Morphogenesis

The 22 γ-Protocadherin (γ-Pcdh) cell adhesion molecules are critical for the elaboration of complex dendritic arbors in the cerebral cortex. Here, we provide evidence that the γ-Pcdhs negatively regulate synapse development by inhibiting the postsynaptic cell adhesion molecule, neuroligin-1 (Nlg1)....

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Bibliographic Details
Main Authors: Michael J. Molumby, Rachel M. Anderson, Dillan J. Newbold, Norah K. Koblesky, Andrew M. Garrett, Dietmar Schreiner, Jason J. Radley, Joshua A. Weiner
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Cell Reports
Subjects:
synapse formation
synaptogenesis
synapse maturation
cell adhesion
spine morphology
spine maturation
neurexin
Pcdh
Protocadherin
Protocadherins
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717302759

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http://www.sciencedirect.com/science/article/pii/S2211124717302759

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