Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells

Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells

It is unclear how the microenvironment of the aorta-gonad-mesonephros influences haematopoietic stem cell (HSC) production early in mouse development. Here, Souilhol et al. use an in vitroaggregate system as a tool to understand how several pathways, BMP, SCF and Shh, may regulate HSC production.

Bibliographic Details
Main Authors: Céline Souilhol, Christèle Gonneau, Javier G. Lendinez, Antoniana Batsivari, Stanislav Rybtsov, Heather Wilson, Lucia Morgado-Palacin, David Hills, Samir Taoudi, Jennifer Antonchuk, Suling Zhao, Alexander Medvinsky
Format: Article
Language:English
Published: Nature Publishing Group 2016-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10784

Internet

https://doi.org/10.1038/ncomms10784

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