Ancestral resurrection reveals evolutionary mechanisms of kinase plasticity

Ancestral resurrection reveals evolutionary mechanisms of kinase plasticity

Protein kinases have evolved diverse specificities to enable cellular information processing. To gain insight into the mechanisms underlying kinase diversification, we studied the CMGC protein kinases using ancestral reconstruction. Within this group, the cyclin dependent kinases (CDKs) and mitogen...

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Bibliographic Details
Main Authors: Conor J Howard, Victor Hanson-Smith, Kristopher J Kennedy, Chad J Miller, Hua Jane Lou, Alexander D Johnson, Benjamin E Turk, Liam J Holt
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-10-01
Series:eLife
Subjects:
protein kinase
evolution
ancestral reconstruction
cyclin-dependent kinase
Ime2
phosphoregulatory network
Online Access:https://elifesciences.org/articles/04126

Internet

https://elifesciences.org/articles/04126

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