RNA G-quadruplexes at upstream open reading frames cause DHX36- and DHX9-dependent translation of human mRNAs

RNA G-quadruplexes at upstream open reading frames cause DHX36- and DHX9-dependent translation of human mRNAs

Abstract Background RNA secondary structures in the 5′-untranslated regions (5′-UTR) of mRNAs are key to the post-transcriptional regulation of gene expression. While it is evident that non-canonical Hoogsteen-paired G-quadruplex (rG4) structures somehow contribute to the regulation of translation i...

Full description

Bibliographic Details
Main Authors: Pierre Murat, Giovanni Marsico, Barbara Herdy, Avazeh Ghanbarian, Guillem Portella, Shankar Balasubramanian
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Genome Biology
Subjects:
Translation regulation
RNA secondary structures
G-quadruplexes
Helicases
Upstream open reading frames
Online Access:http://link.springer.com/article/10.1186/s13059-018-1602-2

Internet

http://link.springer.com/article/10.1186/s13059-018-1602-2

Similar Items