Four subgroups based on tau levels in Alzheimer’s disease observed in two independent cohorts

Four subgroups based on tau levels in Alzheimer’s disease observed in two independent cohorts

Abstract Background As Alzheimer’s disease (AD) pathology presents decades before dementia manifests, unbiased biomarker cut-points may more closely reflect presence of pathology than clinically defined cut-points. Currently, unbiased cerebrospinal fluid (CSF) tau cut-points are lacking. Methods We...

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Bibliographic Details
Main Authors: Flora H. Duits, Kirsten E. J. Wesenhagen, Laura Ekblad, Emma Wolters, Eline A. J. Willemse, ADNI, Philip Scheltens, Wiesje M. van der Flier, Charlotte E. Teunissen, Pieter Jelle Visser, Betty M. Tijms
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
CSF tau
Gaussian mixture modelling
Prognosis
Online Access:https://doi.org/10.1186/s13195-020-00713-3

Internet

https://doi.org/10.1186/s13195-020-00713-3

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