High-fat diet decreases activity of the oxidative phosphorylation complexes and causes nonalcoholic steatohepatitis in mice

High-fat diet decreases activity of the oxidative phosphorylation complexes and causes nonalcoholic steatohepatitis in mice

Nonalcoholic fatty liver disease (NAFLD) is the most frequent histological finding in individuals with abnormal liver-function tests in the Western countries. In previous studies, we have shown that oxidative phosphorylation (OXPHOS) is decreased in individuals with NAFLD, but the cause of this mito...

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Bibliographic Details
Main Authors: Inmaculada García-Ruiz, Pablo Solís-Muñoz, Daniel Fernández-Moreira, Montserrat Grau, Francisco Colina, Teresa Muñoz-Yagüe, José A. Solís-Herruzo
Format: Article
Language:English
Published: The Company of Biologists 2014-11-01
Series:Disease Models & Mechanisms
Subjects:
Mitochondrial respiratory chain
Nonalcoholic steatohepatitis
NADPH oxidase
Oxidative phosphorylation
Proteomic
Nitro-oxidative stress
Online Access:http://dmm.biologists.org/content/7/11/1287

Internet

http://dmm.biologists.org/content/7/11/1287

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