Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data

Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data

Abstract We introduce quanTIseq, a method to quantify the fractions of ten immune cell types from bulk RNA-sequencing data. quanTIseq was extensively validated in blood and tumor samples using simulated, flow cytometry, and immunohistochemistry data. quanTIseq analysis of 8000 tumor samples revealed...

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Bibliographic Details
Main Authors: Francesca Finotello, Clemens Mayer, Christina Plattner, Gerhard Laschober, Dietmar Rieder, Hubert Hackl, Anne Krogsdam, Zuzana Loncova, Wilfried Posch, Doris Wilflingseder, Sieghart Sopper, Marieke Ijsselsteijn, Thomas P. Brouwer, Douglas Johnson, Yaomin Xu, Yu Wang, Melinda E. Sanders, Monica V. Estrada, Paula Ericsson-Gonzalez, Pornpimol Charoentong, Justin Balko, Noel Filipe da Cunha Carvalho de Miranda, Zlatko Trajanoski
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Genome Medicine
Subjects:
Cancer immunology
Immunotherapy
Deconvolution
RNA-seq
Immune contexture
Online Access:http://link.springer.com/article/10.1186/s13073-019-0638-6

Internet

http://link.springer.com/article/10.1186/s13073-019-0638-6

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