A Novel Mutation in the NBD Domain of NLRC4 Causes Mild Autoinflammation With Recurrent Urticaria

A Novel Mutation in the NBD Domain of NLRC4 Causes Mild Autoinflammation With Recurrent Urticaria

BackgroundNOD-like receptor family CARD-containing 4 protein (NLRC4) is a cytosolic protein that forms an inflammasome in response to flagellin and type 3 secretion system (T3SS) proteins from invading Gram-negative bacteria. NLRC4 mutations have been recently identified in early-onset severe autoin...

Full description

Bibliographic Details
Main Authors: Li Wang, Wen Wen, Mengyue Deng, Yue Li, Gan Sun, Xiaodong Zhao, Xuemei Tang, Huawei Mao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
NLRC4
novel mutation
autoinflammatory disease
mild phenotype
urticaria
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.674808/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.674808/full

Similar Items