Evaluation of Long-Time Decoction-Detoxicated Hei-Shun-Pian (Processed Aconitum carmichaeli Debeaux Lateral Root With Peel) for Its Acute Toxicity and Therapeutic Effect on Mono-Iodoacetate Induced Osteoarthritis

Evaluation of Long-Time Decoction-Detoxicated Hei-Shun-Pian (Processed Aconitum carmichaeli Debeaux Lateral Root With Peel) for Its Acute Toxicity and Therapeutic Effect on Mono-Iodoacetate Induced Osteoarthritis

BackgroundAs a degenerative joint disease with severe cartilage destruction and pain, osteoarthritis (OA) has no satisfactory therapy to date. In traditional Chinese medicine (TCM), Aconitum carmichaeli Debeaux derived Hei-shun-pian (Hsp) has been developed for joint pain treatment. However, it caus...

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Bibliographic Details
Main Authors: Lei Zhang, Ting Li, Rongrong Wang, Jiaan Xu, Li Zhou, Li Yan, Zhengyan Hu, Hongwen Li, Fucun Liu, Wenxi Du, Peijian Tong, Huiling Wu, Shanxing Zhang, Letian Shan, Thomas Efferth
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Pharmacology
Subjects:
Aconitum carmichaeli
traditional Chinese medicine
osteoarthritis
monosodium iodoacetate
pain behaviour
analgesia
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01053/full

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https://www.frontiersin.org/article/10.3389/fphar.2020.01053/full

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