Polymer model with Epigenetic Recoloring Reveals a Pathway for the de novo Establishment and 3D Organization of Chromatin Domains
One of the most important problems in development is how epigenetic domains can first be established, and then maintained, within cells. To address this question, we propose a framework that couples three-dimensional chromatin folding dynamics to a “recoloring” process modeling the writing of epigen...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Physical Society
2016-12-01
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| Series: | Physical Review X |
| Online Access: | http://doi.org/10.1103/PhysRevX.6.041047 |