Ibuprofen prevents progression of ataxia telangiectasia symptoms in ATM-deficient mice

Ibuprofen prevents progression of ataxia telangiectasia symptoms in ATM-deficient mice

Abstract Background Inflammation plays a critical role in accelerating the progression of neurodegenerative diseases, such as Alzheimer’s disease (AD) and ataxia telangiectasia (A-T). In A-T mouse models, LPS-induced neuroinflammation advances the degenerative changes found in cerebellar Purkinje ne...

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Bibliographic Details
Main Authors: Chin Wai Hui, Xuan Song, Fulin Ma, Xuting Shen, Karl Herrup
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Journal of Neuroinflammation
Subjects:
Ataxia telangiectasia
Ibuprofen
Anti-inflammatory
Microglia
Purkinje cell
Online Access:http://link.springer.com/article/10.1186/s12974-018-1338-7

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http://link.springer.com/article/10.1186/s12974-018-1338-7

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