MEST promotes lung cancer invasion and metastasis by interacting with VCP to activate NF-κB signaling

MEST promotes lung cancer invasion and metastasis by interacting with VCP to activate NF-κB signaling

Abstract Background Cell invasion is a hallmark of metastatic cancer, leading to unfavorable clinical outcomes. In this study, we established two highly invasive lung cancer cell models (A549-i8 and H1299-i8) and identified mesoderm-specific transcript (MEST) as a novel invasive regulator of lung ca...

Full description

Bibliographic Details
Main Authors: Yang Wang, Jing Zhang, Yang-Jia Li, Nan-Nan Yu, Wan-Ting Liu, Jun-Ze Liang, Wen Wen Xu, Zheng-Hua Sun, Bin Li, Qing-Yu He
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Lung cancer
MEST
VCP
NF-κB
Metastasis
Online Access:https://doi.org/10.1186/s13046-021-02107-1

Internet

https://doi.org/10.1186/s13046-021-02107-1

Similar Items