Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.

Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.

The ecotropic viral integration site 1 (Evi1) oncogenic transcription factor is one of a number of alternative transcripts encoded by the Mds1 and Evi1 complex locus (Mecom). Overexpression of Evi1 has been observed in a number of myeloid disorders and is associated with poor patient survival. It is...

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Bibliographic Details
Main Authors: Emilie A Bard-Chapeau, Dorota Szumska, Bindya Jacob, Belinda Q L Chua, Gouri C Chatterjee, Yi Zhang, Jerrold M Ward, Fatma Urun, Emi Kinameri, Stéphane D Vincent, Sayadi Ahmed, Shoumo Bhattacharya, Motomi Osato, Archibald S Perkins, Adrian W Moore, Nancy A Jenkins, Neal G Copeland
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3937339?pdf=render

Internet

http://europepmc.org/articles/PMC3937339?pdf=render

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