Increased mAb production in amplified CHO cell lines is associated with increased interaction of CREB1 with transgene promoter

Increased mAb production in amplified CHO cell lines is associated with increased interaction of CREB1 with transgene promoter

Most therapeutic monoclonal antibodies in biopharmaceutical processes are produced in Chinese hamster ovary (CHO) cells. Technological advances have rendered the selection procedure for higher producers a robust protocol. However, information on molecular mechanisms that impart the property of hyper...

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Bibliographic Details
Main Authors: Hussain Dahodwala, Prashant Kaushik, Vijay Tejwani, Chih-Chung Kuo, Patrice Menard, Michael Henry, Bjorn G. Voldborg, Nathan E. Lewis, Paula Meleady, Susan T. Sharfstein
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:Current Research in Biotechnology
Subjects:
Chromatin immunoprecipitation (ChIP)
CHO cell line selection
Nuclear proteomics
Transcriptional regulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2590262819300061

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http://www.sciencedirect.com/science/article/pii/S2590262819300061

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