Iron overload inhibits self‐renewal of human pluripotent stem cells via DNA damage and generation of reactive oxygen species

Iron overload inhibits self‐renewal of human pluripotent stem cells via DNA damage and generation of reactive oxygen species

Iron overload affects the cell cycle of various cell types, but the effect of iron overload on human pluripotent stem cells has not yet been reported. Here, we show that the proliferation capacities of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) were signific...

Full description

Bibliographic Details
Main Authors: Zhenbo Han, Zihang Xu, Lei Chen, Danyu Ye, Yang Yu, Ying Zhang, Yang Cao, Bamba Djibril, Xiaofei Guo, Xinlu Gao, Wenwen Zhang, Meixi Yu, Shenzhen Liu, Gege Yan, Mengyu Jin, Qi Huang, Xiuxiu Wang, Bingjie Hua, Chao Feng, Fan Yang, Wenya Ma, Yu Liu
Format: Article
Language:English
Published: Wiley 2020-05-01
Series:FEBS Open Bio
Subjects:
cell cycle
DNA damage
human embryonic stem cells
human induced pluripotent stem cells
iron overload
ROS
Online Access:https://doi.org/10.1002/2211-5463.12811

Internet

https://doi.org/10.1002/2211-5463.12811

Similar Items