Shank3-mutant mice lacking exon 9 show altered excitation/inhibition balance, enhanced rearing, and spatial memory deficit

Shank3-mutant mice lacking exon 9 show altered excitation/inhibition balance, enhanced rearing, and spatial memory deficit

Shank3 is a postsynaptic scaffolding protein implicated in synapse development and autism spectrum disorders. The Shank3 gene is known to produce diverse splice variants whose functions have not been fully explored. In the present study, we generated mice lacking Shank3 exon 9 (Shank3∆9 mice), and t...

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Bibliographic Details
Main Authors: Jiseok eLee, Changuk eChung, Seungmin eHa, Dongmin eLee, Do-Young eKim, Hyun eKim, Eunjoon eKim
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Memory
Synaptic Transmission
autism
hyperactivity
E/I ratio
Shank3
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00094/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00094/full

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