Metformin Inhibits the Urea Cycle and Reduces Putrescine Generation in Colorectal Cancer Cell Lines

Metformin Inhibits the Urea Cycle and Reduces Putrescine Generation in Colorectal Cancer Cell Lines

The urea cycle (UC) removes the excess nitrogen and ammonia generated by nitrogen-containing compound composites or protein breakdown in the human body. Research has shown that changes in UC enzymes are not only related to tumorigenesis and tumor development but also associated with poor survival in...

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Bibliographic Details
Main Authors: Tao Zhang, Ling Hu, Jia-Feng Tang, Hang Xu, Kuan Tian, Meng-Na Wu, Shi-Ying Huang, Yu-Mei Du, Peng Zhou, Rui-Jin Lu, Shuang He, Jia-Mei Xu, Jian-Jun Si, Jing Li, Di-Long Chen, Jian-Hua Ran
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Molecules
Subjects:
metformin
colorectal cancer (CRC)
p53
proliferation
urea cycle
human colorectal cancer HCT116 cell line
Online Access:https://www.mdpi.com/1420-3049/26/7/1990

Internet

https://www.mdpi.com/1420-3049/26/7/1990

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