A Universal Approach to Optimize the Folding and Stability of Prefusion-Closed HIV-1 Envelope Trimers

A Universal Approach to Optimize the Folding and Stability of Prefusion-Closed HIV-1 Envelope Trimers

Summary: The heavily glycosylated native-like envelope (Env) trimer of HIV-1 is expected to have low immunogenicity, whereas misfolded forms are often highly immunogenic. High-quality correctly folded Envs may therefore be critical for developing a vaccine that induces broadly neutralizing antibodie...

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Bibliographic Details
Main Authors: Lucy Rutten, Yen-Ting Lai, Sven Blokland, Daphne Truan, Ilona J.M. Bisschop, Nika M. Strokappe, Annemart Koornneef, Danielle van Manen, Gwo-Yu Chuang, S. Katie Farney, Hanneke Schuitemaker, Peter D. Kwong, Johannes P.M. Langedijk
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718304066

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http://www.sciencedirect.com/science/article/pii/S2211124718304066

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