Association between methylation of BIN1 promoter in peripheral blood and preclinical Alzheimer’s disease

Abstract The bridging integrator 1 (BIN1) gene is the second most important susceptibility gene for late-onset Alzheimer’s disease (LOAD) after apolipoprotein E (APOE) gene. To explore whether the BIN1 methylation in peripheral blood changed in the early stage of LOAD, we included 814 participants (...

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Bibliographic Details
Main Authors: Hao Hu, Lan Tan, Yan-Lin Bi, Wei Xu, Lin Tan, Xue-Ning Shen, Xiao-He Hou, Ya-Hui Ma, Qiang Dong, Jin-Tai Yu
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-021-01218-9