Imbalanced expression of Vcan mRNA splice form proteins alters heart morphology and cellular protein profiles.

Imbalanced expression of Vcan mRNA splice form proteins alters heart morphology and cellular protein profiles.

The fundamental importance of the proteoglycan versican to early heart formation was clearly demonstrated by the Vcan null mouse called heart defect (hdf). Total absence of the Vcan gene halts heart development at a stage prior to the heart's pulmonary/aortic outlet segment growth. This creates...

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Bibliographic Details
Main Authors: Tara A Burns, Maria T Dours-Zimmermann, Dieter R Zimmermann, Edward L Krug, Susana Comte-Walters, Leticia Reyes, Monica A Davis, Kevin L Schey, John H Schwacke, Christine B Kern, Corey H Mjaatvedt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3930639?pdf=render

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http://europepmc.org/articles/PMC3930639?pdf=render

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