The HIV-1 Tat protein induces the activation of CD8+ T cells and affects in vivo the magnitude and kinetics of antiviral responses.

The HIV-1 Tat protein induces the activation of CD8+ T cells and affects in vivo the magnitude and kinetics of antiviral responses.

T cells are functionally compromised during HIV infection despite their increased activation and proliferation. Although T cell hyperactivation is one of the best predictive markers for disease progression, its causes are poorly understood. Anti-tat natural immunity as well as anti-tat antibodies in...

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Bibliographic Details
Main Authors: Francesco Nicoli, Valentina Finessi, Mariaconcetta Sicurella, Lara Rizzotto, Eleonora Gallerani, Federica Destro, Aurelio Cafaro, Peggy Marconi, Antonella Caputo, Barbara Ensoli, Riccardo Gavioli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3817196?pdf=render

Internet

http://europepmc.org/articles/PMC3817196?pdf=render

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